Isolates of Cryptococcus neoformans from Infected Animals Reveal Genetic Exchange in Unisexual, Mating Type Populations †
نویسندگان
چکیده
Isolates of Cryptococcus neoformans from Infected Animals Reveal Genetic Exchange in Unisexual, Mating Type Populations † Tien Bui, Xiaorong Lin,‡ Richard Malik, Joseph Heitman, and Dee Carter* Discipline of Microbiology, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia; Post Graduate Foundation of Veterinary Science and Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia; and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710
منابع مشابه
Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations.
Sexual reproduction and genetic exchange are important for the evolution of fungal pathogens and for producing potentially infective spores. Studies to determine whether sex occurs in the pathogenic yeast Cryptococcus neoformans var. grubii have produced enigmatic results, however: basidiospores are the most likely infective propagules, and clinical isolates are fertile and genetically diverse,...
متن کاملUnisexual Reproduction of Cryptococcus gattii
Cryptococcus gattii is a basidiomycetous human fungal pathogen that typically causes infection in tropical and subtropical regions and is responsible for an ongoing outbreak in immunocompetent individuals on Vancouver Island and in the Pacific Northwest of the US. Pathogenesis of this species may be linked to its sexual cycle that generates infectious propagules called basidiospores. A marked p...
متن کاملDiploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating
The ubiquitous environmental human pathogen Cryptococcus neoformans is traditionally considered a haploid fungus with a bipolar mating system. In nature, the alpha mating type is overwhelmingly predominant over a. How genetic diversity is generated and maintained by this heterothallic fungus in a largely unisexual alpha population is unclear. Recently it was discovered that C. neoformans can un...
متن کاملαADα Hybrids of Cryptococcus neoformans: Evidence of Same-Sex Mating in Nature and Hybrid Fitness
Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction involves two individuals with opposite mating types/sexes, alpha and a. However, the overwhelming predominance of mating type (MAT) alpha over a in C. neoformans populations limits alpha-a mating in natur...
متن کاملPheromone independent unisexual development in Cryptococcus neoformans
The fungus Cryptococcus neoformans can undergo a-α bisexual and unisexual reproduction. Completion of both sexual reproduction modes requires similar cellular differentiation processes and meiosis. Although bisexual reproduction generates equal number of a and α progeny and is far more efficient than unisexual reproduction under mating-inducing laboratory conditions, the α mating type dominates...
متن کامل